translated from Russian
Picamilon increases blood supply and functional state of the brain, increases
microcirculation and hemodynamics of the eyes, and enables improved arterial
blood supply to internal organs. It possesses nootropic, anti-hypoxic and
antioxidant properties; is retained for a long time in body tissues; it is
mildly toxic. In addition, Picamilon renders tranquilizing (not causing
myorelaxation, sleepiness or apathy), and psychostimulating effects, restores
physical and mental working ability after overwork, and lessens the suppressing
influence of ethanol on the central nervous system.
Indications for use
Picamilon is used in the capacity of a nootropic and vasoactive agent for acute
ischemic disturbances of the cerebral blood circulation of mild to moderate
severity; and also during various stages of the restorative period, for
discirculatory encephalopathy, vegetative dystonia, craniocerebral traumas and
neuroinfections. It is recommended for prevention and stopping assaults of the
simple form of migraine.
Preparation is indicated by conditions accompanied by
anxiety, fear, and elevated irritability; by the asthenic states caused by
various neuro-psychological illnesses or connected with increased physical and
mental stress, depressive disorders of the elderly, or senile psychosis.
It is used in complex therapy for stopping acute alcoholic
intoxication. With chronic alcoholism—for decreasing asthenic and
asthenoneurotic, post-psychotic, pre-relapse states, and also for alcoholic
In opthalmological practice, for primary open-angle
glaucoma with normalized intraocular pressure, and for diseases of the retina
and the optic nerve.
In urological practice Picamilon is used in children and
adults with urinary disorders for the purpose of an improvement in the adaptive
function of the urinary bladder.
Methods of treatment and dosage
For discirculative encephalopathy, 20-50mg 3 times per
day. A course of treatment lasts from 1-2 months, and may be repeated after 5-6
For prevention of migraine, tablets of 50mg 3 times per
day; for treating an attack use 100mg in a single dose.
For asthenic states, 40-80mg per diem, in unusual cases
up to 200-300mg per day, for the duration of 1 to 1.5 months.
For depressive states in the elderly, 40-200mg per day in
2-3 doses, for the duration of 1.5 to 3 months.
For restoration of working ability and with increased
workload, 60-200mg per day for 1 to 1.5 months; for athletes the same dose for
2 weeks of the training period.
For alcoholism in a period of abstinence, 100-150mg per
day for the duration of 6-7 days; for more prolonged breakdowns or relapses a
daily dose of 0.04-0.06g.
For treatment of primary open-angle glaucoma, 50mg 3
times per day for the duration of 1 month. In opthalmological practice after
intramuscular or parabulbar introduction, depending on conditions, from 20-50mg 3 times per day, or
60-150mg per day for duration of 1 month.
For functional disorders of urination in children, 20mg 2
times per day for children 3-10 years; 20mg 3 times per day for children over
10 years. For organic disorders of urination caused by myelodysplasia, 20mg 3
times per day for children under 10 years; 50mg 2 times per day for children
11-15 years; and 50mg 3 times per day for children over 15 years. A course of
treatment is 30 days.
For disorders of urination in adults, 50mg 3 times per
day. A course of treatment is 4-6 weeks.
Use of Picamilon is contraindicated in cases of acute sensitivity to the
preparation, or acute severe illnesses of the kidneys.
A Unique Domestic Preparation With a Wide Spectrum of Action
Translated from Russian
The beginning of the 1970s and subsequent years is
characterized by the appearance of a new class of medicinal preparations, called
nootropics, which are finding increasingly wider applications in various areas
of medicine. Nootropic preparations are applied successfully for breakdowns of
memory, attention, learning, and for treatment of loss of brain blood
circulation, brain trauma, chronic alcoholism and other disorders. Among the
medicinal properties of this group a notable place is occupied by the domestic
preparation Picamilon, synthesized in 1969 by the All-Union Scientific Research
Institute and studied in the NII pharmacological RAN . By chemical structure Picamilon is a derivative of the gamma-amino-butyric acid (GABA) and nicotinic
acid. The preparation was introduced in medical practice in 1986, and to the
present time has achieved sufficiently large experience in its application.
The great interest of clinicians in Picamilon may be
attributed to the unique combination of its pharmacological properties. It
possesses high cerebrovascular activity, which exceeds the effect of cinnarizine,
papaverine, xanthinol niacinate, and piracetam. One of the most important
components in the spectrum of psychotropic activity is its nootropic effect,
which determines its clinical use to a significant degree. The preparation has a
unique tranquilizing effect (the manifestation of action is inferior to
diazepam); in this case the preparation does not cause a myorelaxation effect.
The important property of Picamilon is the ability to quickly restore mental and
physical fitness for work, which was lost through overstress. Clinical
experience with application of Picamilon shows that it is effective for ischemic
disturbances of cerebral blood circulation, discirculatory encephalopathy,
vegetative dystonia, and for prevention and treatment of the simple form of
migraine. Picamilon has proven an effective medicinal treatment for patients
with disorders of a neurotic level, with accompanying manifestations of anxiety,
fear, emotional and vegetative instability. Picamilon finds a use in the complex
treatment of alcoholism and acute alcoholic intoxication. At this time the list
of indications for prescription of Picamilon is constantly growing. Clinical
studies have shown that Picamilon possesses favorable properties in
opthalmological practice in the treatment of primary open glaucoma, diseases of
the retina and the optic nerve of vascular genesis. It has been adapted also in
urological practice for treatment of neurological disorders of urination in
children and adults. It is important to note that the use of this preparation
does not cause habituation, but its safety is proven for 10 years in wide and
intensive clinical application. Picamilon is prescribed both in mono-preparation
and in combination with other medicinal agents.
The fact of the varied spectrum of therapeutic action,
noted by many clinicians, testifies to the possibility of a wider application of
Picamilon in the capacity of a medicinal and preventative agent.