Picamilon
   translated from Russian

Pharmacological properties
Picamilon increases blood supply and functional state of the brain, increases microcirculation and hemodynamics of the eyes, and enables improved arterial blood supply to internal organs.  It possesses nootropic, anti-hypoxic and antioxidant properties; is retained for a long time in body tissues; it is mildly toxic.  In addition, Picamilon renders tranquilizing (not causing myorelaxation, sleepiness or apathy), and psychostimulating effects, restores physical and mental working ability after overwork, and lessens the suppressing influence of ethanol on the central nervous system.

Indications for use
Picamilon is used in the capacity of a nootropic and vasoactive agent for acute ischemic disturbances of the cerebral blood circulation of mild to moderate severity; and also during various stages of the restorative period, for discirculatory encephalopathy, vegetative dystonia, craniocerebral traumas and neuroinfections.  It is recommended for prevention and stopping assaults of the simple form of migraine.

Preparation is indicated by conditions accompanied by anxiety, fear, and elevated irritability; by the asthenic states caused by various neuro-psychological illnesses or connected with increased physical and mental stress, depressive disorders of the elderly, or senile psychosis.

It is used in complex therapy for stopping acute alcoholic intoxication. With chronic alcoholism—for decreasing asthenic and asthenoneurotic, post-psychotic, pre-relapse states, and also for alcoholic encephalopathy.

In opthalmological practice, for primary open-angle glaucoma with normalized intraocular pressure, and for diseases of the retina and the optic nerve.

In urological practice Picamilon is used in children and adults with urinary disorders for the purpose of an improvement in the adaptive function of the urinary bladder.

Methods of treatment and dosage

For discirculative encephalopathy, 20-50mg 3 times per day. A course of treatment lasts from 1-2 months, and may be repeated after 5-6 months.

For prevention of migraine, tablets of 50mg 3 times per day; for treating an attack use 100mg  in a single dose.

For asthenic states, 40-80mg per diem, in unusual cases up to 200-300mg per day, for the duration of 1 to 1.5 months.

For depressive states in the elderly, 40-200mg per day in 2-3 doses, for the duration of 1.5 to 3 months.

For restoration of working ability and with increased workload, 60-200mg per day for 1 to 1.5 months; for athletes the same dose for 2 weeks of the training period.

For alcoholism in a period of abstinence, 100-150mg per day for the duration of 6-7 days; for more prolonged breakdowns or relapses a daily dose of 0.04-0.06g.

For treatment of primary open-angle glaucoma, 50mg 3 times per day for the duration of 1 month.  In opthalmological practice after intramuscular or parabulbar introduction, depending on conditions, from 20-50mg 3 times per day, or 60-150mg per day for duration of 1 month.

For functional disorders of urination in children, 20mg 2 times per day for children 3-10 years; 20mg 3 times per day for children over 10 years. For organic disorders of urination caused by myelodysplasia, 20mg 3 times per day for children under 10 years; 50mg  2 times per day for children 11-15 years; and 50mg  3 times per day for children over 15 years. A course of treatment is 30 days.

For disorders of urination in adults, 50mg 3 times per day. A course of treatment is 4-6 weeks.

Contraindications
Use of Picamilon is contraindicated in cases of acute sensitivity to the preparation, or acute severe illnesses of the kidneys.

 



                                                                       
                                                                          
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Picamilon
 
A Unique Domestic Preparation With a Wide Spectrum of Action
 
Translated from Russian

The beginning of the 1970s and subsequent years is characterized by the appearance of a new class of medicinal preparations, called nootropics, which are finding increasingly wider applications in various areas of medicine.  Nootropic preparations are applied successfully for breakdowns of memory, attention, learning, and for treatment of loss of brain blood circulation, brain trauma, chronic alcoholism and other disorders. Among the medicinal properties of this group a notable place is occupied by the domestic preparation Picamilon, synthesized in 1969 by the All-Union Scientific Research Institute and studied in the NII pharmacological RAN . By chemical structure Picamilon is a derivative of the gamma-amino-butyric acid (GABA) and nicotinic acid. The preparation was introduced in medical practice in 1986, and to the present time has achieved sufficiently large experience in its application.

The great interest of clinicians in Picamilon may be attributed to the unique combination of its pharmacological properties.  It possesses high cerebrovascular activity, which exceeds the effect of cinnarizine, papaverine, xanthinol niacinate, and piracetam.  One of the most important components in the spectrum of psychotropic activity is its nootropic effect, which determines its clinical use to a significant degree. The preparation has a unique tranquilizing effect (the manifestation of action is inferior to diazepam); in this case the preparation does not cause a myorelaxation effect. The important property of Picamilon is the ability to quickly restore mental and physical fitness for work, which was lost through overstress. Clinical experience with application of Picamilon shows that it is effective for ischemic disturbances of cerebral blood circulation, discirculatory encephalopathy, vegetative dystonia, and for prevention and treatment of the simple form of migraine. Picamilon has proven an effective medicinal treatment for patients with disorders of a neurotic level, with accompanying manifestations of anxiety, fear, emotional and vegetative instability. Picamilon finds a use in the complex treatment of alcoholism and acute alcoholic intoxication.  At this time the list of indications for prescription of Picamilon is constantly growing.  Clinical studies have shown that Picamilon possesses favorable properties in opthalmological practice in the treatment of primary open glaucoma, diseases of the retina and the optic nerve of vascular genesis.  It has been adapted also in urological practice for treatment of neurological disorders of urination in children and adults. It is important to note that the use of this preparation does not cause habituation, but its safety is proven for 10 years in wide and intensive clinical application. Picamilon is prescribed both in mono-preparation and in combination with other medicinal agents.

The fact of the varied spectrum of therapeutic action, noted by many clinicians, testifies to the possibility of a wider application of Picamilon in the capacity of a medicinal and preventative agent.

                    
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Picamilon Testimonials

Picamilon is the best product I've ever used.  I have tried Paxil, Zoloft, SAMe, and Rhodiola.  SAMe worked well for awhile but then didn't seem to work anymore.Rhodiola is good but nothing compares to Picamilon.

VD
Long Beach, CA

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Picamilon helped my anxiety when none of the drugs the doctor prescribed worked for me.

TM
Las Vegas, NV

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I ordered your Picamilon recently and after just a few days I notice a huge
difference. I've suffered from anxiety/panic/depression for years and I now
believe the missing link was GABA. Literally within a couple days my anxiety
is gone and so is the rest of my depression. This is easily the best
supplement I've ever tried and is the only one that lives up to it's claims.
I'll definitely be ordering more in the future. Thanks!

AM
Bloomington, IN
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Smart Nutrition

Picamilon has given me a new lease on life. It took 6-8 weeks for me to feel the effects but now every day is a pleasure and I'm on top of the world.  Picamilon works well for both anxiety and depression.

Michael McCarthy
Malibu, CA


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Picamilon has worked very well for me and I regularly order extra bottles to give to someone I think may need it.  My doctor had not been the same person since his wife died 3 years ago.  He agreed to try the bottle of picamilon that I gave him and he later said, "Picamilon has transformed my life. Life has taken on new meaning for me."
Another person I know was in a suicidal depression and I convinced him to take the picamilon I gave him.  Within 3 days he came out of his depression.  Another doctor I persuaded to take picamilon said, "I don't know if the picamilon is responsible but I feel so much better since I started taking it."

SM

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Picamilon is great!  I've dealt with an anxiety disorder for a number of years and all the prescription drugs are no good. This stuff is marvelous.

SP

 
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