effects of pyritinol in normal volunteers.
Hindmarch I, Coleston DM, Kerr JS.
HPRU, Robens Institute,
University of Surrey, Guildford, UK.
Twelve healthy male volunteers
received pyritinol 600 or 1,200 mg or placebo for 3 days according to a
randomised, double-blind crossover design. On the 1st and 3rd days of each of
the three treatment periods subjects completed a battery of psychological
tests including Critical Flicker Fusion (CFFT), Choice Reaction Time (CRT),
tests of memory and subjective drug effects at 1, 2, 4 and 6 h after dosing.
Significant improvements in CFFT and CRT were found after pyritinol. There
were no significant differences on the other tests, however, the observed
enhancement in performance could be attributed to the effect of the drug.